MyBioSource.com's ITM2B antibody is a Mouse monoclonal antibody. The ITM2B antibody was generated using Bri, BRI2, and ITM2B as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
Mouse monoclonal ITM2B antibody
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides whichform the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition ofbeta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia